Format

Send to

Choose Destination
Arthritis Res Ther. 2011 Jun 24;13(3):115. doi: 10.1186/ar3351.

IL-17 in spondyloarthritis: is the T-party over?

Abstract

The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into the cellular source of IL-17, originally identified as the signature cytokine of a distinct CD4(+) T-cell subset known as Th17. Accumulating evidence suggests that the majority of the IL-17 released in inflammatory arthritis is produced by innate immune cells rather than T cells. Understanding molecular mechanisms behind these early innate immune responses will be the key to designing rational therapies targeting these important inflammatory pathways.

PMID:
21722352
PMCID:
PMC3218894
DOI:
10.1186/ar3351
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center