Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cell Mol Med. 2011 Oct;15(10):2025-39. doi: 10.1111/j.1582-4934.2011.01374.x.

Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.

Author information

  • 1School of Medicine, NUI Galway, Galway, Ireland.

Abstract

The stimuli for neuronal cell death in neurodegenerative disorders are multi-factorial and may include genetic predisposition, environmental factors, cellular stressors such as oxidative stress and free radical production, bioenergy failure, glutamate-induced excitotoxicity, neuroinflammation, disruption of Ca(2+) -regulating systems, mitochondrial dysfunction and misfolded protein accumulation. Cellular stress disrupts functioning of the endoplasmic reticulum (ER), a critical organelle for protein quality control, leading to induction of the unfolded protein response (UPR). ER stress may contribute to neurodegeneration in a range of neurodegenerative disorders. This review summarizes the molecular events occurring during ER stress and the unfolded protein response and it specifically evaluates the evidence suggesting the ER stress response plays a role in neurodegenerative disorders.

PMID:
21722302
PMCID:
PMC4394214
DOI:
10.1111/j.1582-4934.2011.01374.x
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center