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Traffic. 2011 Oct;12(10):1318-26. doi: 10.1111/j.1600-0854.2011.01244.x. Epub 2011 Jul 27.

ESCRT machinery and cytokinesis: the road to daughter cell separation.

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Department of Infectious Diseases, King's College London School of Medicine, Guy's Hospital, London SE1 9RT, UK.


The endosomal sorting complex required for transport (ESCRT) machinery is a set of cellular protein complexes required for at least three topologically equivalent membrane scission events, namely multivesicular body (MVB) formation, retroviral particle release and midbody abscission during cytokinesis. Recently, several studies have explored the mechanism by which the core ESCRT-III subunits mediate membrane scission and might be differentially required according to the functions of the pathway. In this review, we discuss the links between the ESCRT machinery and cytokinesis, with special focus on abscission initiation and regulation.

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