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Clin Microbiol Infect. 2012 Jan;18(1):54-60. doi: 10.1111/j.1469-0691.2011.03478.x. Epub 2011 Jul 1.

Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections.

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Infectious Diseases Unit, Sheba Medical Center, Tel Hashomer, Israel.


The aim of this study was to evaluate the impact of carbapenem-resistant K. pneumoniae bloodstream infections on mortality. During the study period 42, 68 and 120 patients were identified with carbapenem-resistant, extended-spectrum β-lactamase producers (ESBL) and susceptible K. pneumoniae bloodstream infections, respectively. Patients with carbapenem-resistant K. pneumoniae had higher rates of prior antimicrobial exposure, other nosocomial infections, and use of invasive devices. Infection-related mortality was 48% for carbapenem-resistant, 22% for ESBL producers and 17% for susceptible K. pneumoniae. Independent risk factors for infection-related mortality were Pitt bacteraemia score, Charlson score and carbapenem resistance.

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