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J Biomed Opt. 2011 Jun;16(6):066020. doi: 10.1117/1.3584847.

In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury.

Author information

1
Washington University, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130-4899, USA.

Abstract

For the first time, we have implemented photoacoustic tomography (PAT) to image the water content of an edema in vivo. We produced and imaged a cold-induced cerebral edema transcranially, then obtained blood vessel and water accumulation images at 610 and 975 nm, respectively. We tracked the changes at 12, 24, and 36 h after the cold injury. The blood volume decreased after the cold injury, and the maximum area of edema was observed 24 h after the cold injury. We validated PAT of the water content of the edema through magnetic Resonance Imaging and the water spectrum from the spectrophotometric measurement.

PMID:
21721821
PMCID:
PMC3124533
DOI:
10.1117/1.3584847
[Indexed for MEDLINE]
Free PMC Article

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