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J Biomed Opt. 2011 Jun;16(6):066016. doi: 10.1117/1.3593149.

Megahertz streak-mode Fourier domain optical coherence tomography.

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1
Clemson University, Department of Bioengineering, COMSET, Clemson, South Carolina 29634, USA.

Abstract

Here we present an ultrahigh-speed Fourier-domain optical coherence tomography (OCT) that records the OCT spectrum in streak mode with a high-speed area scan camera, which allows higher OCT imaging speed than can be achieved with a line-scan camera. Unlike parallel OCT techniques that also use area scan cameras, the conventional single-mode fiber-based point-scanning mechanism is retained to provide a confocal gate that rejects multiply scattered photons from the sample. When using a 1000 Hz resonant scanner as the streak scanner, 1,016,000 A-scans have been obtained in 1 s. This method's effectiveness has been demonstrated by recording in vivo OCT-image sequences of embryonic chick hearts at 1000 frames/s. In addition, 2-megahertz OCT data have been obtained with another high speed camera.

PMID:
21721817
PMCID:
PMC3144967
DOI:
10.1117/1.3593149
[Indexed for MEDLINE]
Free PMC Article
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