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J Gastrointest Surg. 2011 Sep;15(9):1548-55. doi: 10.1007/s11605-011-1615-6.

Clostridium difficile colitis: factors associated with outcome and assessment of mortality at a national level.

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1
Department of Surgery, Division of Colon & Rectal Surgery, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA. dstewart@hmc.psu.edu

Abstract

BACKGROUND:

Previous descriptions of Clostridium difficile colitis (CDC) epidemics may overestimate cost and mortality of CDC.

METHODS:

An analysis of the 2007 Nationwide Inpatient Sample was performed. Patients with CDC (N = 41,207) were compared to a propensity score-matched cohort of patients without CDC.

RESULTS:

Average length of stay was longer for CDC patients by 5 days (p < 0.001). Mortality was higher for the CDC cohort (9.4% vs. 8.6%; p < 0.001) though the absolute difference was small. Mean hospital costs were 56% higher for CDC patients (p < 0.001). Higher odds of death with CDC were associated with small hospitals and self-pay patients. Chronic renal failure and diabetes were associated with lower hospital costs and lower odds of death in the CDC cohort.

CONCLUSIONS:

CDC is not as deadly of a disease as it may be perceived to be at larger hospitals, and mortality was actually unaffected by certain serious comorbidities. CDC is expensive due to a longer hospital stay.

PMID:
21720924
DOI:
10.1007/s11605-011-1615-6
[Indexed for MEDLINE]
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