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Indian Pediatr. 2011 Aug;48(8):637-9. Epub 2011 May 30.

Management of lower limb deformities in children with osteogenesis imperfecta.

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Department of Pediatrics, Apollo Center for Advanced Pediatrics, Indraprastha Apollo Hospital, New Delhi, India.


Osteogenesis imperfecta (OI) often leads to severe lower limb (LL) deformities due to recurrent fractures that significantly hamper ambulation. We describe our management experience of correction of LL deformities in four children with OI. Medical management consisted of peri and postoperative pamidronate therapy, calcium supplementation and rehabilitative care. Deformities were corrected with multiple osteotomies and intramedullary fixation by titanium elastic nails. At a mean follow-up of 30 months, all children have significantly reduced fracture incidence and have no evidence of recurrence of deformities with improved ambulatory status. We emphasize the importance of combined medical and surgical therapy for these patients.

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