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Trends Endocrinol Metab. 2011 Sep;22(9):364-73. doi: 10.1016/j.tem.2011.05.003. Epub 2011 Jun 28.

MafA and MafB activity in pancreatic β cells.

Author information

1
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

Analyses in mouse models have revealed crucial roles for MafA (musculoaponeurotic fibrosarcoma oncogene family A) and MafB in islet β cells, with MafB being required during development and MafA in adults. These two closely related transcription factors regulate many genes essential for glucose sensing and insulin secretion in a cooperative and sequential manner. Significantly, the switch from MafB to MafA expression also appears to be vital for functional maturation of β cells produced by human embryonic stem (hES) cell differentiation. This review summarizes the discovery, distribution, and function of MafA and MafB in rodent pancreatic β cells, and describes some key questions regarding their importance to β cells.

PMID:
21719305
PMCID:
PMC3189696
DOI:
10.1016/j.tem.2011.05.003
[Indexed for MEDLINE]
Free PMC Article

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