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Chin J Cancer. 2011 Jul;30(7):442-9. doi: 10.5732/cjc.011.10040.

Mouse models of medulloblastoma.

Author information

1
Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, Toronto, Ontario, M5G 1L7, Canada.

Abstract

Medulloblastoma is the most common malignant pediatric brain tumor. Despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of human diseases, including cancer, and serve a valuable role as preclinical models for testing targeted therapies. In this review, we summarize how such models have been successfully applied to the study of medulloblastoma over the past decade and what we might expect in the coming years.

PMID:
21718590
PMCID:
PMC4013419
DOI:
10.5732/cjc.011.10040
[Indexed for MEDLINE]
Free PMC Article

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