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J Org Chem. 2011 Aug 5;76(15):6447-51. doi: 10.1021/jo2011329. Epub 2011 Jul 11.

Copper-catalyzed oxidative direct cyclization of N-methylanilines with electron-deficient alkenes using molecular oxygen.

Author information

1
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.

Abstract

The oxidative direct cyclizaion of N-methylanilines with electron-deficient alkenes involving maleimides and benzylidene malononitriles through sp(3) and sp(2) C-H bond cleavage proceeds effectively under a CuCl(2)/O(2) catalysis to provide the corresponding tetrahydroquinolines in good yields.

PMID:
21718039
DOI:
10.1021/jo2011329

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