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Genes Dev. 2011 Jul 15;25(14):1464-9. doi: 10.1101/gad.2060311. Epub 2011 Jun 29.

The relative ratio of condensin I to II determines chromosome shapes.

Author information

1
Chromosome Dynamics Laboratory, RIKEN Advanced Science Institute, Saitama, Japan.

Abstract

To understand how chromosome shapes are determined by actions of condensins and cohesin, we devised a series of protocols in which their levels are precisely changed in Xenopus egg extracts. When the relative ratio of condensin I to II is forced to be smaller, embryonic chromosomes become shorter and thicker, being reminiscent of somatic chromosomes. Further depletion of condensin II unveils its contribution to axial shortening of chromosomes. Cohesin helps juxtapose sister chromatid arms by collaborating with condensin I and counteracting condensin II. Thus, chromosome shaping is achieved by an exquisite balance among condensin I and II and cohesin.

PMID:
21715560
PMCID:
PMC3143936
DOI:
10.1101/gad.2060311
[Indexed for MEDLINE]
Free PMC Article

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