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Bioinformatics. 2011 Aug 15;27(16):2279-87. doi: 10.1093/bioinformatics/btr391. Epub 2011 Jun 27.

Integration and visualization of host-pathogen data related to infectious diseases.

Author information

1
Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA.

Abstract

MOTIVATION:

Infectious disease research is generating an increasing amount of disparate data on pathogenic systems. There is a growing need for resources that effectively integrate, analyze, deliver and visualize these data, both to improve our understanding of infectious diseases and to facilitate the development of strategies for disease control and prevention.

RESULTS:

We have developed Disease View, an online host-pathogen resource that enables infectious disease-centric access, analysis and visualization of host-pathogen interactions. In this resource, we associate infectious diseases with corresponding pathogens, provide information on pathogens, pathogen virulence genes and the genetic and chemical evidences for the human genes that are associated with the diseases. We also deliver the relationships between pathogens, genes and diseases in an interactive graph and provide the geolocation reports of associated diseases around the globe in real time. Unlike many other resources, we have applied an iterative, user-centered design process to the entire resource development, including data acquisition, analysis and visualization.

AVAILABILITY AND IMPLEMENTATION:

Freely available at http://www.patricbrc.org; all major web browsers supported.

CONTACT:

cmao@vbi.vt.edu

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

PMID:
21712250
PMCID:
PMC3150046
DOI:
10.1093/bioinformatics/btr391
[Indexed for MEDLINE]
Free PMC Article

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