Format

Send to

Choose Destination
See comment in PubMed Commons below
Hum Genomics. 2011 May;5(4):310-5.

Pathway annotation and analysis with Reactome: the solute carrier class of membrane transporters.

Author information

1
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. bj1@ebi.ac.uk

Abstract

Reactome is an expert-authored, peer-reviewed knowledge base of human reactions and pathways that functions as a data-mining resource and electronic textbook. Its current release covers approximately 23 per cent of the complete human proteome from UniProt. The pathway browser, search and data-mining tools facilitate searching and visualising pathway data and the analysis of user-supplied high-throughput datasets. A catalogue of all the solute-carrier (SLC) class of transporters which have known ligands has been annotated in Reactome. Reactome provides a detailed and interactive view of this set of transport reactions. Using the example of the SLC class of transporters, we show how they can be overlaid with protein-protein interaction, protein-drug interaction and gene expression data and compared with equivalent pathways in other species, to facilitate over-representation, expression and other pathway analyses.

PMID:
21712192
PMCID:
PMC3525243
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center