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Cancer Biother Radiopharm. 2011 Jun;26(3):317-24. doi: 10.1089/cbr.2010.0892. Epub 2011 Jun 28.

Molecular mechanism of silymarin-induced apoptosis in a highly metastatic lung cancer cell line anip973.

Author information

1
Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shannxi, P.R. China.

Abstract

BACKGROUND:

Silymarin, the main flavonoid constituent element extracted from Silybum marianum possessing antioxidant activity, is already known to be able to block the NF-κB activation process and result in cell apoptosis, implicating silymarin's potential to control cancer cell growth.

MATERIALS AND METHODS:

In this study, based upon the above assumption, silymarin was administered to a highly metastatic lung cancer cell line Anip973 to test silymarin's role in cancer cell proliferation.

RESULTS:

Silymarin had significant inhibitory effects on the proliferation of Anip973 cells in a dose-dependent and time-response manner within 48 hours. Silymarin can induce Anip973 apoptosis.

CONCLUSIONS:

Silymarin may in vitro inhibit the proliferation of the human lung adenocarcinoma cell line Anip973 and induce apoptosis via the mitochondria-dependent caspase cascade pathway.

PMID:
21711112
DOI:
10.1089/cbr.2010.0892
[Indexed for MEDLINE]

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