Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Toxicol. 2012 Feb;86(2):165-81. doi: 10.1007/s00204-011-0726-x. Epub 2011 Jun 28.

Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances.

Author information

1
Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA. dms6@cornell.edu

Abstract

Synthetic pyrethroid insecticides were introduced into widespread use for the control of insect pests and disease vectors more than three decades ago. In addition to their value in controlling agricultural pests, pyrethroids are at the forefront of efforts to combat malaria and other mosquito-borne diseases and are also common ingredients of household insecticide and companion animal ectoparasite control products. The abundance and variety of pyrethroid uses contribute to the risk of exposure and adverse effects in the general population. The insecticidal actions of pyrethroids depend on their ability to bind to and disrupt voltage-gated sodium channels of insect nerves. Sodium channels are also important targets for the neurotoxic effects of pyrethroids in mammals but other targets, particularly voltage-gated calcium and chloride channels, have been implicated as alternative or secondary sites of action for a subset of pyrethroids. This review summarizes information published during the past decade on the action of pyrethroids on voltage-gated sodium channels as well as on voltage-gated calcium and chloride channels and provides a critical re-evaluation of the role of these three targets in pyrethroid neurotoxicity based on this information.

Comment in

PMID:
21710279
PMCID:
PMC3218237
DOI:
10.1007/s00204-011-0726-x
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center