Format

Send to

Choose Destination
Pregnancy Hypertens. 2011 Jan 1;1(1):17-21. doi: 10.1016/j.preghy.2010.10.007.

Preeclampsia and the Anti-Angiogenic State.

Author information

1
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Abstract

Preeclampsia is a major cause of maternal and fetal morbidity and mortality worldwide, however, its etiology remains unclear. Abnormal placental angiogenesis during pregnancy resulting from high levels of anti-angiogenic factors, soluble Flt1 (sFlt1) and soluble endoglin (sEng), has been implicated in preeclampsia pathogenesis. Accumulating evidence also points to a role for these anti-angiogenic proteins as serum biomarkers for the clinical diagnosis and prediction of preeclampsia. Uncovering the mechanisms of altered angiogenic factors in preeclampsia may also provide insights into novel preventive and therapeutic options.

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center