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Transfus Apher Sci. 2011 Aug;45(1):53-9. doi: 10.1016/j.transci.2011.06.003. Epub 2011 Jun 25.

The cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia.

Author information

1
Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway. tor.brynjar.stuge@uit.no

Abstract

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal antibodies that cross the placenta in connection with pregnancy and destroy fetal platelets. Recently, maternal T cell responses associated with FNAIT have been studied at the clonal level. These T cell clones recognize an integrin β3 epitope, which is anchored to the HLA-DRB3∗0101-encoded MHC molecule DR52a. The same MHC allele is strongly associated with FNAIT. As the production of pathological antibodies reactive with fetal platelets is likely dependent on these T cell responses, there exists a potential for preventing FNAIT by targeting these T cells.

PMID:
21708486
DOI:
10.1016/j.transci.2011.06.003
[Indexed for MEDLINE]

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