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Cell Microbiol. 2011 Aug;13(8):1122-9. doi: 10.1111/j.1462-5822.2011.01619.x. Epub 2011 Jun 24.

The bacterial second messenger c-di-GMP: mechanisms of signalling.

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1
Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.

Abstract

Cyclic-di-GMP (c-di-GMP) regulates many important bacterial processes. Freely diffusible intracellular c-di-GMP is determined by the action of metabolizing enzymes that allow integration of numerous input signals. c-di-GMP specifically regulates multiple cellular processes by binding to diverse target molecules. This review highlights important questions in research into the mechanisms of c-di-GMP signalling and its role in bacterial physiology.

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