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Lett Appl Microbiol. 2011 Sep;53(3):374-8. doi: 10.1111/j.1472-765X.2011.03109.x.

Evolution of antimicrobial resistance of Acinetobacter baumannii in a university hospital.

Author information

1
Department of Basic Health Sciences, State University of Maringá, Maringá, Paraná, Brazil.

Abstract

AIMS:

To investigate the susceptibility pattern and the molecular epidemiology of Acinetobacter baumannii isolates in two periods (1994-1996 and 2004-2007) in Londrina University Hospital.

METHODS AND RESULTS:

Antimicrobial susceptibility of 150 A. baumannii isolates was assessed by disc diffusion and agar dilution methods. Genetic similarity amongst the isolates was evaluated by ERIC-PCR. Resistance of A. baumannii to carbapenems increased from 2% (1994-1996) to 73% (2004-2007). Thirty-eight clones were detected.

CONCLUSIONS:

The results of the study suggest that the high prevalence of carbapenem resistance amongst Acinetobacter baumannii organisms in this institution is not caused by the spread of a predominant clone.

SIGNIFICANCE AND IMPACT OF THE STUDY:

This work reinforces the importance monitoring antimicrobial susceptibility rates.

[Indexed for MEDLINE]
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