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J Bacteriol. 2011 Aug;193(16):4278-9. doi: 10.1128/JB.00377-11. Epub 2011 Jun 24.

Genome sequence of Streptomyces sp. strain Tü6071.

Author information

1
Institute of Pharmaceutical Sciences, Pharmaceutical Bioinformatics, University of Freiburg, Hermann-Herder-Strasse 9, 79104 Freiburg, Germany.

Abstract

Streptomyces sp. Tü6071 is a soil-dwelling bacterium which has a highly active isoprenoid biosynthesis. Isoprenoids are important precursors for biopharmaceutical molecules such as antibiotics or anticancer agents, e.g., landomycin. Streptomyces sp. Tü6071 produces the industrially important terpene glycosides phenalinolactones, which have antibacterial activity against several Gram-positive bacteria. The availability of the genome sequence of Streptomyces sp. Tü6071 allows for understanding the biosynthesis of these pharmaceutical molecules and will facilitate rational genome modification to improve industrial use.

PMID:
21705604
PMCID:
PMC3147684
DOI:
10.1128/JB.00377-11
[Indexed for MEDLINE]
Free PMC Article

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