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Parkinsonism Relat Disord. 2011 Sep;17(8):635-7. doi: 10.1016/j.parkreldis.2011.06.001. Epub 2011 Jun 25.

Impulse control disorders in Chinese Parkinson's disease patients: the effect of ergot derived dopamine agonist.

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1
Department of Medicine, Pamela Youde Nethersole Eastern Hospital, 3rd Lok Man Road, Chai Wan, Hong Kong Special Administrative Region, China. auyema@yahoo.com.hk

Abstract

OBJECTIVE:

We studied the prevalence and related risk factors of impulse control disorders in Chinese Parkinson's disease patients.

METHOD:

We screened all non-demented Parkinson's disease patients attending our Parkinson's disease clinic from August 2009 to March 2010. The clinical characteristics of patients with impulse control disorders and those without were compared.

RESULTS:

Of the 213 PD subjects screened, 15 (7.0%) with impulse control disorders were identified. Fourteen of these subjects were on both a dopamine agonist and Levodopa, and one was on Levodopa alone. Of the fourteen subjects on both a dopamine agonist and Levodopa, eleven were on bromocriptine and Levodopa; 10.5% of the subjects exposed to bromocriptine had impulse control disorder. Upon multivariate analysis, dose of dopamine agonist used, young age at onset of Parkinson's disease and a history of anxiety or depression were independent predictors for developing impulse control disorders.

CONCLUSIONS:

7% of our Chinese PD subjects had impulse control disorders. When young Parkinson's disease patients with a history of anxiety or depression are treated with high dose of DA, they are at risk of developing impulse control disorders.

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