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Drug Discov Today. 2011 Sep;16(17-18):779-92. doi: 10.1016/j.drudis.2011.06.004. Epub 2011 Jun 15.

Drug discovery in the next decade: innovation needed ASAP.

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Vertex Pharmaceuticals, 130 Waverly St., Cambridge, MA 02139, USA.


Pharmaceutical companies must find a better way to increase their output of truly new drugs for the benefit of patients and for their business survival. Here, I highlight a general perspective from within pharmaceutical research as it pertains to research advances in chemistry, biology, pharmacology, pharmacokinetics and toxicology that, if well integrated, stands to put the industry on a productive path. In addition, I provide a complementary perspective on the corporate culture aspect of innovation. I also introduce a new concept, termed 'innovation ASAP' (iASAP; asking powerful questions, seeking the outliers, accepting defeat and populating astutely) and provide support for it using examples of several successful drugs.

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