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Immunity. 2011 Jun 24;34(6):821-2. doi: 10.1016/j.immuni.2011.06.006.

NOD so fast: NLRX1 puts the brake on inflammation.

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Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.


In this issue of Immunity, Allen et al. (2011) and Xia et al. (2011) provide in vivo and biochemical evidence that NLRX1, a member of the nucleotide binding domain and leucine-rich-repeat-containing protein family, functions as a negative regulator of RIG-I and Toll-like receptors.

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