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Int J Immunopharmacol. 1990;12(5):539-44.

Differential suppression of T-cell subpopulations by thc (delta-9-tetrahydrocannabinol).

Author information

1
University of South Florida College of Medicine, Tampa 33612.

Abstract

THC (delta-9-tetrahydrocannabinol), the major psychoactive component of marijuana, has been shown to suppress various immune functions in vivo and in vitro. THC suppresses murine T-lymphocyte proliferation; however, the effects on T-cell subsets remain unclear. We have stimulated cultured murine splenocytes with the mitogens concanavalin A (Con A) or phytohemagglutinin (PHA) while exposing them to varying concentrations of THC. After three days, the cells were analyzed by the fluorescent activated cell sorter for the following T-cell markers--Thy1, L3T4 and Ly2. The Ly2 cells represent the suppressor/effector T-cells while L3T4 cells represent the helper T-cell subpopulations. The results show that the dose response suppressive effect of THC on T-cell proliferation reflects a preferential inhibition of Ly2 vs L3T4 cells. The effects of THC on other functional parameters are in the process of investigation.

PMID:
2170281
DOI:
10.1016/0192-0561(90)90118-7
[Indexed for MEDLINE]

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