Send to

Choose Destination
See comment in PubMed Commons below
J Mol Neurosci. 2012 Jan;46(1):210-6. doi: 10.1007/s12031-011-9580-9. Epub 2011 Jun 24.

Prothrombin G20210A and factor V Leiden polymorphisms in stroke.

Author information

  • 1Laboratory of Genetic and Molecular Pathology, Medical School, Hassan II University, 19, rue Tarik-Ibn-Ziad, BP 9154, 10000, Casablanca, Morocco.


The molecular epidemiology of stroke is critically lacking in the developing world. We explored the relationships between genetics polymorphism and risk for ischemic stroke among the residents of Casablanca, Morocco. Ninety-one stroke patients matched 1:2 for their age, gender, and ethnic background to 182 healthy controls who were genotyped for the prothrombin G20210A mutation and factor V (FV) Leiden and were assessed for conventional risk factors for stroke. No significant association was found between prothrombin gene mutation with stroke (p = .054). Regarding stroke subtypes, significant relationships between patients with a large artery disease subtype of stroke and this mutation was found compared to controls (p = .046). As a genetic risk factor to develop this event, a strong association was observed when adjusted for conventional vascular risk factors (adjusted OR, 4.3; p = .029). No FV Leiden was found. We suggest that prothrombin mutation but not FV Leiden should be considered as a modest genetic risk factor for large artery disease stroke subtype in the Moroccan population.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center