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Nat Rev Cancer. 2011 Jun 24;11(7):503-11. doi: 10.1038/nrc3057.

Pro-senescence therapy for cancer treatment.

Author information

1
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA.

Abstract

Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.

PMID:
21701512
DOI:
10.1038/nrc3057
[Indexed for MEDLINE]
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