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Science. 2011 Jun 24;332(6037):1571-6. doi: 10.1126/science.1202249.

Inducing sleep by remote control facilitates memory consolidation in Drosophila.

Author information

1
Department of Anatomy and Neurobiology, Washington University in St. Louis, St. Louis, MO 63110, USA.

Abstract

Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.

PMID:
21700877
PMCID:
PMC4064462
DOI:
10.1126/science.1202249
[Indexed for MEDLINE]
Free PMC Article

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