Send to

Choose Destination
Epilepsy Res. 2011 Sep;96(1-2):172-5. doi: 10.1016/j.eplepsyres.2011.05.012. Epub 2011 Jun 22.

The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms.

Author information

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.


The ketogenic diet (KD) is a treatment of infantile spasms (IS). Here, we examine the efficacy of KD in medically refractory IS, examine its impact on growth in infants, and explore its mechanism of action. At 1-3 months after the initiation of the KD, 46% of twenty-six patients had a greater than 90% reduction in IS. No significant relationships between reduction in IS and serum β-hydroxybutyrate, or glucose levels were identified. Also, the KD had not significantly altered patient's growth parameters. Thus, in corroborating with prior studies, we demonstrate the KD is a well-tolerated and efficacious treatment of IS.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center