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Mol Cell. 2011 Jun 24;42(6):715-7. doi: 10.1016/j.molcel.2011.06.004.

No country for old misfolded glycoproteins.

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  • 1Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA.


Gauss et al. (2011) present evidence that an endoplasmic reticulum (ER) sugar-removing enzyme with a folding sensor subunit enables a stochastic quality control mechanism, which marks with increasing probability misfolded glycoproteins for destruction the longer they reside in the ER.

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