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Infect Agent Cancer. 2011 Jun 23;6(1):7. doi: 10.1186/1750-9378-6-7.

Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile.

Author information

1
Virology Program, I.C.B.M., Faculty of Medicine, University of Chile, Independencia 1027, Santiago 838-9100, Chile.
2
Department of Public Health, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.
3
Department of Public Heath, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
4
Pathology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
5
Division of Oncogenic and Persistent Viruses, Center for Chronic Viral Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.
6
Department of Hematology and Oncology, Pontificia Universidad Catolica, 85 Lira Street, Santiago 133-202, Santiago, Chile.
#
Contributed equally

Abstract

BACKGROUND:

Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined.

RESULTS:

The amplification of a housekeeping gene showed that 46/55 samples (84%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7%) and EBV was detected in 3/46 (6.5%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013).

CONCLUSIONS:

The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC.

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