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PLoS One. 2011;6(6):e20580. doi: 10.1371/journal.pone.0020580. Epub 2011 Jun 16.

Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.

Author information

1
Research Program's Unit, Molecular Medicine and Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

Abstract

DCDC2 is one of the candidate susceptibility genes for dyslexia. It belongs to the superfamily of doublecortin domain containing proteins that bind to microtubules, and it has been shown to be involved in neuronal migration. We show that the Dcdc2 protein localizes to the primary cilium in primary rat hippocampal neurons and that it can be found within close proximity to the ciliary kinesin-2 subunit Kif3a. Overexpression of DCDC2 increases ciliary length and activates Shh signaling, whereas downregulation of Dcdc2 expression enhances Wnt signaling, consistent with a functional role in ciliary signaling. Moreover, DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia.

PMID:
21698230
PMCID:
PMC3116825
DOI:
10.1371/journal.pone.0020580
[Indexed for MEDLINE]
Free PMC Article

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