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Pediatr Infect Dis J. 2011 Nov;30(11):992-5. doi: 10.1097/INF.0b013e3182253c54.

Mitochondrial impact of human immunodeficiency virus and antiretrovirals on infected pediatric patients with or without lipodystrophy.

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1
Mitochondrial Functionalism Laboratory, University of Barcelona, IDIBAPS, Hospital Clínic of Barcelona, Barcelona, Spain. cmoren1@clinic.ub.es

Abstract

We determined the mitochondrial status of a group of HIV-infected children, some with body fat abnormalities (BFA). We included 24 controls, 16 HIV-infected untreated, 26 HIV-infected treated, 6 BFA-untreated, and 21 BFA-treated patients. Genetic, translational, and functional mitochondrial values were measured. As compared with controls, mitochondrial DNA depletion and a reduction in functionality were found in BFA groups.

PMID:
21697766
DOI:
10.1097/INF.0b013e3182253c54
[Indexed for MEDLINE]
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