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J Clin Psychopharmacol. 2011 Aug;31(4):512-6. doi: 10.1097/JCP.0b013e3182228619.

Switching antidepressant class does not improve response or remission in treatment-resistant depression.

Author information

1
Laboratoire de Psychologie Médicale, Université Libre de Bruxelles, and Centre Européen de Psychologie Médicale-PsyPluriel, Brussels, Belgium.

Abstract

OBJECTIVE:

The management of treatment-resistant depression is a much debated issue. In particular, the evidence supporting the commonly suggested sequential use of antidepressants from 2 different pharmacological classes is weak. This retrospective study was undertaken to investigate whether there is a better response in nonresponders switched to a different class of antidepressants (across-class) compared with nonresponders switched to an antidepressant from the same class (within-class).

METHODS:

Three hundred forty patients with primary major depressive disorder were recruited in the context of a European multicenter project. Subjects whose current depressive episode had failed to respond to a first antidepressant trial of adequate dose and duration were included.

RESULTS:

There was no significant difference in response or remission rates between the across-class and within-class groups after controlling for possible confounders.

CONCLUSIONS:

In depressed nonresponders to a previous antidepressant treatment, switching to a different class of antidepressants was not associated with a better response or remission rate.

PMID:
21694617
DOI:
10.1097/JCP.0b013e3182228619
[Indexed for MEDLINE]

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