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Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 May-Jun;40(3):558-64.

[The effect of the cerebrospinal fluid from patients with manic and depressive syndromes on the social hierarchical relationships in a group of rats].

[Article in Russian]


Taking into account socio-oriented symptoms of affective disorders, a method of zoosocial hierarchy of rats was used for biological testing of the cerebrospinal fluid of patients with manic and depressive syndromes. Cerebrospinal fluid and its fractions were administered before and after treatment by trypsin into suboccipital cistern of "dominants" and "subordinates" of the community. A change of behaviour was observed, the character of which depended on the phase of donor's psychosis. Low-molecular fraction of the cerebrospinal fluid possessed specific activity, which disappeared after the treatment by trypsin, what allowed to suggest oligopeptide nature of the active factors.

[Indexed for MEDLINE]

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