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Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 May-Jun;40(3):535-42.

[Calmodulin blockaders weaken the short-term plasticity of the neuronal cholinoreceptors in the edible snail].

[Article in Russian]


By means of recording transmembrane ion currents of identified snail neurones PPa3 and LPa3 a reversible weakening was shown of the speed and depth of extinction of neuronal cholinoreceptor membrane reactions to repeated iontophoretic applications of acetylcholine to the soma by a number of calmodulin blockaders: R24571 (20-50 mmol/l), trifluoperazine (50-200 mmol/l), chlorpromazine (20-60 mmol/l) and prenylamine lactate (30-400 mmol/l). The obtained results testify to a positive control by calmodulin of short-term cholinoreceptors plasticity of the studied neurons.

[Indexed for MEDLINE]

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