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Clin Infect Dis. 2011 Jul 15;53(2):158-63. doi: 10.1093/cid/cir340.

Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding.

Author information

1
Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York 10595, USA. abhay_dhand@nymc.edu

Abstract

We used daptomycin plus antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface charge induced by ASBLs against daptomycin nonsusceptible MRSA. Addition of ASBLs to daptomycin may be of benefit in refractory MRSA bacteremia. (Although the official designation is "daptomycin nonsusceptiblity," we will use the term "daptomycin-resistance" in this paper for facility of presentation.).

PMID:
21690622
PMCID:
PMC3697476
DOI:
10.1093/cid/cir340
[Indexed for MEDLINE]
Free PMC Article

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