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Front Microbiol. 2011 Jun 3;2:126. doi: 10.3389/fmicb.2011.00126. eCollection 2011.

Immune Control of Legionella Infection: An in vivo Perspective.

Author information

  • 1Department of Microbiology and Immunology, University of Melbourne Parkville, Victoria, Australia.

Abstract

Legionella pneumophila is an intracellular pathogen that replicates within alveolar macrophages. Through its ability to activate multiple host innate immune components, L. pneumophila has emerged as a useful tool to dissect inflammatory signaling pathways in macrophages. However the resolution of L. pneumophila infection in the lung requires multiple cell types and abundant cross talk between immune cells. Few studies have examined the coordination of events that lead to effective immune control of the pathogen. Here we discuss L. pneumophila interactions with macrophages and dendritic cell subsets and highlight the paucity of knowledge around how these interactions recruit and activate other immune effector cells in the lung.

KEYWORDS:

Legionnaire’s disease; cytokines; inflammation; macrophages; plasmacytoid dendritic cells

PMID:
21687433
PMCID:
PMC3109619
DOI:
10.3389/fmicb.2011.00126
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