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Nat Neurosci. 2011 Jun 19;14(7):821-3. doi: 10.1038/nn.2833.

Glia instruct developmental neuronal remodeling through TGF-β signaling.

Author information

1
Department of Neurobiology, University of Massachusetts, Worcester, Massachusetts, USA. awasakit@janelia.hhmi.org

Abstract

We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

PMID:
21685919
PMCID:
PMC3337551
DOI:
10.1038/nn.2833
[Indexed for MEDLINE]
Free PMC Article

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