Format

Send to

Choose Destination
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 May;36(5):405-10. doi: 10.3969/j.issn.1672-7347.2011.05.006.

Effect of human umbilical cord blood stem cells on flash visual evoked potential in traumatic optic neuropathy in rats.

Author information

1
Department of Ophthalmology, Second Xiangya Hospital, Changsha 410011, China.

Abstract

OBJECTIVE:

To investigate the effect of human umbilical cord blood stem cells on flash visual evoked potentials (F-VEP) of the traumatic optic neuropathy rats.

METHODS:

Forty-eight Sprague-Dawley rats were randomly divided into an injury group (Group A) and 3 treatment groups (Groups B, C, and D). A traumatic optic neuropathy model was built in Group A, and the rats in Groups B, C, and D were injected with the neurotrophic factor, human umbilical cord blood stem cells, and the mixture of the neurotrophic factor and human umbilical cord blood stem cells, respectively. F-VEP was recorded in both eyes of rats at the 1st h, 1st week, 2nd week, 3rd week, and 4th week after the optic nerve injury.

RESULTS:

At all time points, there were significant difference in the wave latency and amplitude between Group A and normal control eyes (P<0.01). The differences of the wave latency and amplitude between Group A and Groups B, C, and D were statistically significant at various time points after the injury except for the wave latency at the 1st h post-operation (P<0.05). The amplitude in Group D was higher while the latency was shorter than those of Group B at all time points since the 1st week (P<0.05). The comparisons at the same point in the remaining treatment groups were not significantly different (P<0.05).

CONCLUSION:

The mixture of human umbilical cord blood stem cells and neurotrophic factor has a promotion effect for the recovery of F-VEP of optic nerve in traumatic optic neuropathy in rats to some degrees.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for CENTRAL SOUTH UNIVERSITY
Loading ...
Support Center