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Curr Opin Chem Biol. 2011 Aug;15(4):475-81. doi: 10.1016/j.cbpa.2011.05.024. Epub 2011 Jun 22.

Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).

Author information

1
Interactions et Modulateurs de Réponses (UPR3243), Centre National de la Recherche Scientifique (CNRS) & Université de Provence, 31 Chemin Joseph Aiguier, 13402 Marseille cedex 20, France.

Abstract

Worldwide research efforts have driven recent pharmaceutical successes, and consequently, the emerging role of Protein-Protein Interactions (PPIs) as drug targets has finally been widely embraced by the scientific community. Inhibitors of these Protein-Protein Interactions (2P2Is or i-PPIs) are likely to represent the next generation of highly innovative drugs that will reach the market over the next decade. This review describes up-to-date knowledge on this particular chemical space, with a specific emphasis on a subset of this ensemble. We also address current structural knowledge regarding both protein-protein and protein-inhibitor complexes, that is, the 2P2I database. Finally, ligand efficiency analyses permit us to relate potency to size and polarity and to discuss the need to co-develop nanoparticle drug delivery systems.

PMID:
21684802
DOI:
10.1016/j.cbpa.2011.05.024
[Indexed for MEDLINE]

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