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Toxicol Appl Pharmacol. 2011 Aug 15;255(1):9-17. doi: 10.1016/j.taap.2011.05.011. Epub 2011 May 27.

Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice.

Author information

1
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, CAS, People's Republic of China.

Abstract

Microcystins (MCs), the products of blooming algae Microcystis, are waterborne environmental toxins that have been implicated in the development of liver cancer, necrosis, and even fatal intrahepatic bleeding. Alternative protective approaches in addition to complete removal of MCs in drinking water are urgently needed. In our previous work, we found that sulforaphane (SFN) protects against microcystin-LR (MC-LR)-induced cytotoxicity by activating the NF-E2-related factor 2 (Nrf2)-mediated defensive response in human hepatoma (HepG2) and NIH 3T3 cells. The purpose of this study was to investigate and confirm efficacy the SFN-induced multi-mechanistic defense system against MC-induced hepatotoxicity in an animal model. We report that SFN protected against MC-LR-induced liver damage and animal death at a nontoxic and physiologically relevant dose in BALB/c mice. The protection by SFN included activities of anti-cytochrome P450 induction, anti-oxidation, anti-inflammation, and anti-apoptosis. Our results suggest that SFN may protect mice against MC-induced hepatotoxicity. This raises the possibility of a similar protective effect in human populations, particularly in developing countries where freshwaters are polluted by blooming algae.

PMID:
21684301
PMCID:
PMC3577421
DOI:
10.1016/j.taap.2011.05.011
[Indexed for MEDLINE]
Free PMC Article

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