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Am J Med. 2011 Jul;124(7):578-87. doi: 10.1016/j.amjmed.2010.12.027.

Testosterone deficiency.

Author information

1
Department of Biochemistry, Division of Urology, Boston University School of Medicine, Mass., USA.

Abstract

Testosterone deficiency (TD) afflicts approximately 30% of men aged 40-79 years, with an increase in prevalence strongly associated with aging and common medical conditions including obesity, diabetes, and hypertension. A strong relationship is noted between TD and metabolic syndrome, although the relationship is not certain to be causal. Repletion of testosterone (T) in T-deficient men with these comorbidities may indeed reverse or delay their progression. While T repletion has been largely thought of in a sexual realm, we discuss its potential role in general men's health concerns: metabolic, body composition, and all-cause mortality through the use of a single clinical vignette. This review examines a host of studies, with practical recommendations for diagnosis of TD and T repletion in middle-aged and older men, including an analysis of treatment modalities and areas of concerns and uncertainty.

Comment in

PMID:
21683825
DOI:
10.1016/j.amjmed.2010.12.027
[Indexed for MEDLINE]

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