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Int J Biochem Cell Biol. 2011 Oct;43(10):1422-6. doi: 10.1016/j.biocel.2011.06.002. Epub 2011 Jun 12.

Ubiquitin-dependent mitochondrial protein degradation.

Author information

1
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

Abstract

Progressive mitochondrial failure is tightly associated with the onset of many age-related human pathologies. This tight connection results from the double-edged sword of mitochondrial respiration, which is responsible for generating both ATP and ROS, as well as from risks that are inherent to mitochondrial biogenesis. To prevent and treat these diseases, a precise understanding of the mechanisms that maintain functional mitochondria is necessary. Mitochondrial protein quality control is one of the mechanisms that protect mitochondrial integrity, and increasing evidence implicates the cytosolic ubiquitin/proteasome system (UPS) as part of this surveillance network. In this review, we will discuss our current understanding of UPS-dependent mitochondrial protein degradation, its roles in diseases progression, and insights into future studies.

PMID:
21683801
PMCID:
PMC3163752
DOI:
10.1016/j.biocel.2011.06.002
[Indexed for MEDLINE]
Free PMC Article

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