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Cell Signal. 2011 Oct;23(10):1546-54. doi: 10.1016/j.cellsig.2011.05.022. Epub 2011 Jun 13.

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle.

Author information

1
Program in Cell Biology, The Hospital for Sick Children, Toronto, Canada.

Abstract

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.

PMID:
21683139
DOI:
10.1016/j.cellsig.2011.05.022
[Indexed for MEDLINE]

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