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Eur Radiol. 2011 Nov;21(11):2344-53. doi: 10.1007/s00330-011-2179-2. Epub 2011 Jun 17.

Percutaneous local ablation of unifocal subclinical breast cancer: clinical experience and preliminary results of cryotherapy.

Author information

1
Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, University Hospital "Tor Vergata", viale Oxford 81, 00133 Rome, Italy. guggi@tiscali.it

Abstract

OBJECTIVES:

To assess the ablative effectiveness, the oncological and cosmetic efficacy of image-guided percutaneous cryoablation in the treatment of single breast nodules with subclinical dimensions after identification with ultrasonography (US), mammography, magnetic resonance (MRI) and characterization by vacuum assisted biopsy.

MATERIALS:

Fifteen women with a mean age of 73 ± 5 years (range 64-82 years) and lesion diameter of 8 ± 4 mm were undergoing cryotherapy technology with a single probe under US-guidance associated with intra-procedural lymph-node mapping and excision of the sentinel node. All the patients underwent surgical resection (lumpectomy) from 30 to 45 days after the percutaneous ablation.

RESULTS:

The iceball size generated by the cryoprobe during the procedure at minus 40°C was 16 × 41 mm. In 14 of the 15 patients was observed a complete necrosis of the cryo-ablated lesion both in post-procedural MRI follow-up and anatomo-pathological evaluation after surgical resection. In one case there was a residual disease in post-procedural MRI and postoperative histological examination, probably justified by an incorrect positioning of the probe.

CONCLUSION:

The percutaneous cryoablation as a "minimally invasive" technique can provide excellent oncological and cosmetic results on selected cases handled by experienced operators by using the tested devices.

PMID:
21681574
DOI:
10.1007/s00330-011-2179-2
[Indexed for MEDLINE]

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