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Antimicrob Agents Chemother. 1990 Jun;34(6):1271-2.

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

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1
Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.

Abstract

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.

PMID:
2168148
PMCID:
PMC171799
[Indexed for MEDLINE]
Free PMC Article

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