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Diabet Med. 2011 Nov;28(11):1343-51. doi: 10.1111/j.1464-5491.2011.03360.x.

Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study.

Collaborators (2254)

Absenger G, Albrich E, Allinger B, Allinger S, Anacher G, Angermayr G, Angermeier H, Anzengruber A, Archimanitis G, Arnsteiner P, Auberger W, Azhary M, Barfuss M, Bauer C, Bauer BE, Beclin T, Binder T, Binder G, Böhler D, Brändle J, Breslmair J, Brettlecker M, Bürger M, Calvi I, Dorfinger W, Doringer-Schnepf E, Eer A, Eckmayr C, Eder F, Egermann M, Erath M, Etzinger M, Etzinger C, Fiedler L, Filip W, Filip M, Föchterle J, Fodor A, Frieden T, Gareiss M, Gföllner P, Ghamarian T, Goritschan M, Haar K, Habeler G, Hadjiivanov V, Haiböck C, Hammer R, Hartmann S, Haschkovitz H, Hauer W, Hauer J, Haunschmidt C, Heimayr C, Hengl W, Hengl G, Hermann R, Herrmann R, Hillebrand R, Hintersteininger O, Hirsch M, Hitzinger M, Hochegger T, Hockl W, Hoi M, Hörmann J, Hudler B, Imb G, Joichl A, Jungbauer K, Kapl G, Kerschbaum M, Kienesberger F, Killinger G, Kitzler G, Klein F, Kleinbichler D, Kohr A, Kopetzky M, Korthals C, Kortschak W, Koschutnik M, Kraus WA, Kurzemann S, Lavicka C, Lehner G, Lenz J, Lepuschütz S, Lichtenwallner M, Lober R, Loidl C, Lopatka E, Ludwig R, Maca T, Mair A, Mandak M, Margreiter M, Margreiter A, Markovics M, Matejicek F, Mohilla M, Moll C, Mörz B, Mörz R, Nagl H, Neumayr G, Oberroitmair H, Oberzinner M, Pallamar W, Pangratz S, Parandian L, Paulus A, Pfaffenwimmer C, Plaichinger P, Pokorn T, Polanec H, Pöll-Weiss B, Pralea D, Puttinger J, Quinton T, Ranegger M, Rass S, Rauch H, Riehs M, Robetin E, Rohringer J, Rupprechter J, Sadjed E, Schimbach JA, Schmid J, Schneiderbauer R, Schopper W, Schulze-Bauer A, Schuster G, Schwarz J, Schwarz M, Schweighofer C, Schwelle F, Simma H, Sock R, Sock R, Sprenger F, Stiglmayr T, Stocker I, Stütz P, Tama M, Teleky U, Tschauko W, Veits M, Vikydal G, Vlaschitz K, Wais E, Wais A, Wegmann R, Wehle F, Weindl M, Weinhandl M, Wendt U, Wendt K, Werner-Tutschku V, Werner-Tutschku C, Wilscher J, Wind N, Winter A, Wolfschütz G, Wolfsgruber M, Wolfsgruber B, Wurm R, Ziebart-Schroth A, Zimmermann M, Zinnagl A, Zirm A, Zirm Canada B, Bokenfohr GM, Liu EK, Melling GW, Papp EW, Sachdeva AK, Snyman ER, Varma S, Ward RA, Tiong Wong AP, Basson PJ, Brodie BD, Chahal SJ, Chan WY, Chow JC, Cormack M, Eddy DH, Ezekiel D, Farquhar A, Gu S, Hii TH, Ho-Asjoe MP, Hosie A, Jaffer S, Jakubowski AT, Karim M, Kiai C, Kooy J, Lytle CR, Mcleod KL, Morgan DC, Myckatyn MM, Ng JP, Schriemer R, Schumacher G, Grey Stopforth J, Hoo Tsui WW, Wilson RT, Wong D, Wong WT, Yeung MM, Cram DH, Kumari Dissanayake DT, Gerber JD, Haligowski D, Hrabarchuk B, Kroczak TJ, Lipson AH, Mahay RK, Wessels Mare AC, Mohamdee FJ, Olynyk FT, Pieterse W, Ramgoolam R, Rothova A, Saunders KK, Szajkowski S, Van Gend RF, Van Rensburg NM, Anand S, Baer CE, Basque EJ, Benaya S, Bessoudo R, Bhalla J, Chettiar NV, Craig BN, Desrosiers F, Ranjani Imbulgoda M, Morgan GM, Nowak ZJ, Scott DG, Searles GR, Slorach JN, Stevenson RN, Browne NJ, Bruff KJ, Collingwood JM, Collins W, Over A, Gabriel AM, Govender M, Hart DG, Hatcher LB, Janes J, Kielty JF, Kielty JF, Krisdaphongs M, Lush RB, Moulton WB, Riche CR, Rideout GM, Roberts BC, Walsh PE, Wight HG, Woodland KH, Woodland RC, Atkinson BC, Chow CS, Collins JA, Graham RD, Hosein J, Machel TM, Mahaney G Jr, Mclean JR, Murray MR, Myatt GA, Ozere CP, Saha AK, Sanders DH, Seaman DM, Seaman JG, Swinamer D, Voon Yee KY, Ali MM, Bankay CD, Beduhn EE, Callaghan DJ, Chan YK, Chaudhri AR, Chen RY, Conway JR, Cunningham WL, Cusimano SL, Souza ED, De Souza SX, Deyoung JP, Epstein R, Faiers AA, Figurado VJ, Forbes FB, Gabor Z, Gallardo RC, Gaur SK, George E, Hartford BJ, Shiu-Chung Ho M, Ho C, Ismail SH, Bhushan Kalra B, Koprowicz K, Kumar N, Lam C, Lau MJ, Law HK, Fung ML, Liutkus JF, Lotfallah TK, Luton RG, Meneses GS, Miller ML, Nagji N, Ng KH, Ng Thow Hing RE, Pandey AS, Petrov I, Rosenthall W, Rudner H, Russell AD, Sanchez ZA, Shaban JA, Shariff SB, Shih CM, Sinclair DW, Spink DR, Tung TH, Vizel S, Yanover DF, Zavodni LS, Cusack P, Dewar CM, Hooley P, Kassner RA, Mackinnon RJ, Molyneaux HW, Shetty KN, Barrière G, Berjat MB, Bernucci B, Bérubé C, Boueau G, Chehayeb R, Ciricillo D, Constance CM, Côté G, Desroches J, Gagnon R, Gaueau G, Godbout JL, Harvey P, Hassan Y, Hoang NV, Houde D, Lalonde AP, Lavoie R, Leclair N, Meagher L, Ouimet A, Plourde S, Rioux DW, Roberge C, Roy B, Sasseville R, Serfaty S, Theriault L, Timothée JR, Tjia S, Tremblay B, Turcotte J, Bose S, Aletta Bouwer H, Chernesky PA, Johnson ML, Kemp DR, Lai RP, Lee FR, Lipsett WG, Lombard SJ, Majid FS, Malan JJ, Maree N, Nayar A, Nel M, Oduntan OO, Rajakumar AR, Baraka Ramadan F, Shamsuzzaman M, Vermeulen AP, Fred C, Anthonsen B, Ardest SP, Arnold-Larsen SK, Axelsen A, Barfoed K, Birkler NE, Blokkebak J, Boserup J, Kettrup Brassøe JO, Chovanec M, Lykke Christensen B, Christensen M, Skjøth Christensen R, Eidner PO, Eisbo J, Elsvor J, Engmann IV, Eriksen RM, Frederiksen T, Frølund HC, Garne S, Giørtz A, Gregersen B, Halkier ML, Hansen JG, Harder J, Jørgen H, Henriksen O, Kirkeby Hoffmann M, Holk E, Hollensen J, Jacobsen R, Jakobsen L, Jensen C, Jensen M, Jensen V, Jepsen P, Johannsen JA, Verner Johansen L, Johansen OS, Juul K, Jørgensen AF, Jørgensen P, Jørgensen UM, Kensmark L, Kjellerup C, Kjaer E, Kjaersgaard M, Klubien P, Kolby P, Korsgaard Thomsen K, Krebs P, Kristiansen T, Lyng F, Madsen NV, Meyer-Christensen J, Mogensen O, Mortensen F, Nielsen LM, Nielsen PS, Nielsen SK, Ommen H, Juhl Otte J, Østergaard Paridon V, Parm M, Peampour K, Petersen K, Pilgaard PJ, Poulsen SE, Preisler T, Hast Prins SU, Randløv A, Rasmussen BR, Elmegaard Rasmussen P, Rasmussen R, Roed SF, Sander KF, Schmidt EØ, Jørgen Schultz P, Smidemann M, Solgaard J, Stripp T, Søderlund MR, Søgaard H, Søndergaard DE, Sørensen BH, Sørensen GS, Thøgersen N, Toftdahl H, Uggerhøj H, Uhrenholt B, Veronika Ullisch E, Valentiner-Branth C, Vinberg J, Vinter SA, Vittrup P, Winther-Pedersen N, Wøldike AG, Zederkof JM, Thue Østergaard M, Abiven P, Abraham D, De Beaumais PA, Ado JP, Affres H, Agache R, Winther-Pedersen N, Airault Leman AM, Moussarih AA, Albaric C, Allaouchiche T, Allignol C, Ammor M, Ammoun Bourdelas C, Amsallem L, Anquez D, Antonini JM, Assuied V, Attia G, Audebert O, Audibert H, Ayach C, Bagdadlian S, Bagni M, Baillet J, Ballivian Cardozo F, Baranes R, Barbier P, Barousse F, Bas S, Battaglia JM, Baudonnat B, Bauple JL, Domengetroy FB, Beard T, Beaumier E, Beaumont JF, Baylac Domengetroy F, Beard T, Beaumier E, Beaumont JF, Beck C, Behar M, Behr B, Benady R, Benghanem MM, Benichou H, Bensoussan JM, Bensussan P, Bercegeay P, Berneau JB, Bertolotti A, Bertrand S, Besson A, Bezanson C, Bezier C, Bezzina R, Bichon H, Bickar P, Billot P, Billot Belmere MC, Bisson F, Blanc D, Bloch JL, Bloch B, Blondin H, Blot J, Bloud R, Blouin P, Boesch C, Boiteux JL, Bonnafous P, Bonneau Y, Bonnefoy L, Borg B, Borys JM, Brunehaut Petaut M, Boschmans S, Said RB, Bouallouche A, Bouchet J, Bouchlaghem K, Boulen Y, Bouline B, Bounekhla MS, Bouquin V, Bourgeois MB, Bourgois D, Brandily C, Brandt P, Branquart F, Breilh P, Brilleman F, Brisson T, Brocard F, Bruel P, Brun JP, Brunehaut Petaut M, Buisson JG, Buisson Virmoux I, Bur C, Cabal Malville E, Cabantous S, Cabrol P, Cagnoli Gromovoi S, Caillaux BX, Caillot D, Canchon Ottaviani I, Canu P, Caramella A, Caramella A, Cardaillac C, Carrivale A, Cartal JP, Cassany B, Cauon B, Causeret JM, Caye P, Cayet JP, Cazor G, Cesarini J, Chakra G, Chambeau B, Chambon V, Chanas J, Chapuzot P, Charon A, Charpin E, Charton F, Cheikel J, Chemin P, Chennouf K, Chequel H, Chevrier D, Ciroux P, Cissou Y, Claeys JL, Clariond Y, Classen O, Cloerec A, Clouet S, Cloup Lefeuvre AM, Cochet C, Cocuau D, Cohen H, Cohen Presberg PC, Colin S, Colin R, Colucci R, Come P, Condouret P, Conturie A, Corbin A, Corticelli P, Coste D, Cotrel O, Coueau S, Coulon P, Courdy C, Courtin M, Courtot P, Coutrey L, Couval R, Cravello P, Cressey O, Cuisinier Y, Cunin B, Cunnington B, Cusseau H, Cuvelier C, Arailh BD, Dabboura A, Dages L, Dahmani N, Dandignac JC, Daney D, Dannel B, Darbois D, Dareths P, Daubin D, David JC, De Foiard P, De Mallmann Guyot VD, De Wit MA, Debast F, Deboute E, Debuc JP, Dechoux E, Decloux O, Decruyenaere Y, Dejans JM, Delarue M, Delattre X, Delmaire P, Denis L, Deschamps Ben Ayed M, Devins P, Dezou S, Dieuzaide P, Dirheimer B, Dominguez P, Donadille F, Dondain B, Doridan P, Ouhet P, Dubois A, Dubois A, Ducharme P, Duchez P, Dulard C, Dumoulin M, Duprey G, Durand J, Mohamed I, Chehab E, Emery B, Emmanuel G, Ashari GE, Evrard E, Fargeot Lamy A, Farges JL, Faucher P, Faucie A, Faure Y, Favre JJ, Felipe JL, Feret D, Ferragu A, Ferrandin G, Ferriot F, Finelle L, Flond J, Foieri J, Fol S, Fontaine B, Forichon D, Foucry M, Fournier JF, Fregeac B, Fuchs M, Gabriel F, Gaimard D, Gallois S, Garapon G, Garas M, Garcia P, Garcia JM, Garcia MP, Garman W, Garzuel D, Gaspard JM, Gauci L, Gautheron P, Gauthier J, Gauthier Lafaye PY, Gay MC, Gay Duc B, Gayout O, Gegu Y, Gentile F, Germain E, Gharbi G, Gigandet Tamarelle C, Gilardie A, Gilles Verliat M, Gillet T, Gnana P, Goguey A, Gombert A, Gonin B, Gonzales P, Goulesque X, Graba JM, Granier A, Greiner O, Groboz M, Gromoff S, Grossemy X, Grossi C, Guenin F, Gueranger P, Guerin P, Guerineau JP, Guessous Zghal F, Guicheux D, Guillere J, Guyonnet G, Haddad S, Hadj N, Hamani D, Hamm J, Hammoudi D, Harle X, Harnie Coussau P, Hazen R, Hembert F, Hemon P, Hergue M, Hestin C, Heyraud L, Hindennach D, Hirot E, Ho Wang Yin CS, Hocquelet Denis C, Hoppe P, Horovitz D, Hours JM, Houta B, Hua G, Hui Bon Hoa N, Humez P, Hurier M, Husson G, Hyvernat G, Ichard JF, Impens C, Iovescu D, Jacob P, Jacob P, Jacob G, Jacquemart JP, Jacquier P, Jahanshahi Honorat S, Jalladeau JF, Jan L, Jannel Y, Jarrige V, Jeremiasz R, Annick Jestin Depond M, Joseph M, Joseph M, Joseph Henri Fargue H, Joubrel A, Jouet A, Julien B, Jullien F, Jullien JL, Kadoche D, Kahl E, Kanawati A, Khalife S, Khettou C, Kiers JP, Kissel C, Klein JC, Klopfenstein S, Koch A, Koenig G, Kohler P, Koriche A, Labernardiere N, Labet P, Lablanche F, Laborde Laulhe V, Lagorce X, Laine E, Lalague P, Laleu JN, Lambert M, Lambert Ledain ML, Lambertyn X, Lame JF, Langlois F, Lanoix E, Laprade M, Lasseri C, Laterrade B, Laurent JC, Laurier B, Laval L, Le Borgne P, Le Franc P, Le Henaff P, Le Noir De Carlan H, Le Roy JP, Le Roy Hennion F, Lebon L, Lecler O, Leclerc P, Ledieu C, Lefebvre B, Lefevre P, Lehujeur C, Leiber C, Leick G, Lemberthe T, Lenevez N, Lenoble P, Leriche P, Leroux E, Leroy JM, Leroy C, Lescaillez D, Leurele C, Lhermann S, Libermann P, Licari G, Lo Re A, Long P, Long JL, Lormeau B, Louchart JC, Lucas JP, Luquet T, Lussato P, Maarouf M, Mabilais F, Magnier Sinclair C, Mahot Moreau P, Malafosse D, Mandirac JP, Manolis J, Mante JP, Maquaire C, Marchal T, Marchand G, Marillesse O, Marmier G, Herve Maron Y, Marrachelli N, Marsaux M, Martin B, Martin M, Deiss PM, Masson A, Mativa B, Matton JF, Mauffrey J, Mauriere S, Maurois G, Maury J, Mayer F, Menu P, Mercier B, Messmer D, Mestiri S, Meyer G, Michaelides M, Michaud G, Michenaud B, Mielot S, Millory Marco JA, Mingam S, Mira R, Mius S, Monnier Meteau MP, Mora F, Morbois Trabut L, Morosi L, Mougeolle JL, Mouget JL, Mouroux D, Mouthon JM, Muller J, Nakache A, Narbonne H, Navarranne Roumec A, Navarro P, Neubrand JY, Nguyen QT, Nguyen Quang G, Nguyen Xuan T, Niot P, Oudart JM, Outteryck A, Pages JM, Paillet C, Pain JM, Pangaud De Gouville P, Paquin O, Parent V, Parer Richard C, Parrot F, Parthenay P, Pascariello JC, Passebon JC, Pere A, Perelstein L, Perot M, Petit R, Petit P, Petit F, Petruzzi P, Phelipeau D, Philippon JC, Philippon G, Picard B, Picard JC, Picot B, Piera JF, Pieri A, Piffoux E, Pilard P, Pillet A, Pinot P, Pinzani A, Pleskof A, Plessier JC, Plisson A, Pochon C, Poggi V, Poirat A, Poiree M, Polleux J, Noel Pontecaille J, Posocco R, Pospiech JC, Pradies F, Prevot R, Pueyo JB, Quaelli J, Rabbia M, Rabemananjara A, Rami S, Rapin JJ, Rasquin C, Ratinaud D, Reboud B, Reboul P, Reichman JJ, Reinhardt P, Renard Houta CR, Reverdy O, Revol M, Rey PA, Richardeau Y, Rives B, Robida C, Rochez Fraiberg M, Rodet JP, Rolland JF, Romand B, Romano JP, Rosati Gretere C, Rosey A, Rosset M, Rossi JP, Rouquette G, Rousseau M, Rousselon X, Roy C, Royer D, Ruetsch M, Saade M, Saby Kuchler N, Samar G, Sanchez PY, Sane A, Sanz JP, Sardon M, Sarrazin ME, Sasportes G, Saudou F, Sauze E, Savary P, Schenowitz A, Schmartz P, Schoepfer MO, Seewagen J, Serramoune D, Serre C, Sicard Guroo H, Sichãc JP, Sifaoui S, Simoncello M, Simonin MJ, Simonnet JF, Spindler D, Steier A, Sultan CR, Taghipour K, Talayrach B, Talbot F, Talhouarn V, Tallec Y, Tarasco Schenrey E, Tarrene M, Tater D, Tessier B, Teste M, Thierry D, Thiollier P, Thoreau F, Thual J, Traen V, Trigano JA, Troussier JB, Truong Ky Minh B, Van Melckebeke G, Vaque P, Vaucelle C, Vedel E, Venu D, Verdavoine P, Vergeron J, Viallon P, Viault D, Vieules JM, Vigier JP, Vilain JM, Villard B, Vitoux JF, Viviand P, Vivien O, Walter P, Waquier P, Waszkiewicz JM, Weidich S, Westerfeld R, Weynachter G, Wilhelm P, Wolff C, Wursthorn M, Zammattio D, Zylinski B, Lauer P, Kühn U, Weltzel W, Mohr H, Weyland K, Spittel B, Böhm G, Ferdowsy S, Hanusch P, Spiekermann J, Albert E, Stuff K, Jungmair W, Koller S, Schubert W, Schlehahn F, Bormann G, Graf K, Stiehler G, Bock M, Müller A, Haufe M, Nielsen L, Raum D, Rogler K, Bürstner J, Völk HJ, Sachse M, Escher T, Doumit A, O'Dey H, Holzmann U, Sauer H, Schellenberg G, Carius J, Dänschel W, Kopf A, Zerr E, Tatalovic R, Rupp H, Anders E, Mende M, Volk U, Hagenow A, Lang T, Schmitz KH, Gössling JH, Mutsch G, Steidel J, Osten K, Giokoglu K, Bellisch S, Füll K, Walther W, Flick S, Dünnebier R, Dharmawan I, Schönmehl W, Hoss V, Kipping S, Wolf HJ, Wolf HF, Willmann V, Bugarski B, Hoffschröer J, Von Wallfeld S, Ruhland G, Bulling D, Häusler M, Haustein G, Kallenbach C, Schwemmler C, Frank A, Lodder-Bender U, Rawe K, Reinert HF, Schönhof P, Fahrenschon K, Schorcht E, Etzold E, Brehm M, Paust WD, Schulte-Kemna A, Pötter KW, Ott-Voigtländer U, Schwenke R, Thinesse-Mallwitz M, Siml S, Stern H, Roelen H, Scherhag KP, Matulla P, Herrmann HJ, Neumann G, Barbuia M, Vormann R, Hitzler K, Linum A, Hanke K, Hohberg HJ, Klingel R, Hohnstädter R, Klasen H, Aschermann P, Grau W, Killinger P, Gross K, Naus R, Todoroff K, Zühlke W, Kellner HU, Hager E, Thieme J, Kornitzky M, Rösch V, Heinze E, Hiederer W, Konz KH, Köhler M, Diekmann M, Junghans E, Dietermann F, Kerp E, Schäfer-Lehnhausen S, Kruck I, Ettelt R, Hölscher A, Kittler S, Jung H, Mailänder A, Nowara P, Ritschl H, Mödl B, Gallwitz T, Meyer S, Peter A, Peters O, Pflaum P, Fröhlich KH, Mertens HJ, Merlin-Sprünken V, Erpenbach K, Fervers F, Kuhl U, Halsig F, Rein W, Hauser ER, Laubenthal F, Richard F, Langer C, Lange R, Eska J, Mohanty G, Lange I, Eltges N, Kuntz C, Mechery T, Vöckl J, Viergutz C, Stähle-Klose C, Sohr K, Böhler S, Brecke G, Burls M, Werner KM, Vorpahl R, Stahl-Weigert B, Bunge G, Thomsen J, Blessing E, Bengel B, Buhlmann U, Tröger T, Sippel S, Vossschulte V, Wilms W, Appelt A, Dauterstedt D, Witte W, Böttger U, Wyborski W, Strache S, Böttger W, Zeiner L, Wuttke W, Stoidner- Amann A, Stoermer B, Bock S, Groos-März C, Thamm ME, Meier J, Schneider M, Niessen U, Storm GR, Streitbürger E, Münkel T, Palfi M, Naumann U, Tannhof G, Streibhardt F, Gebhardt W, Nieswandt G, Gerke U, Nöhring A, Bott J, Goertz J, Winkler D, Lotter E, Kraaz K, Bärwinkel P, Hildebrandt D, Weyers G, Kubin-Siring B, Baier E, Weber T, Holz DE, Wolfers J, Kihm W, Kamali-Ernst S, Amann W, Kaase HJ, Banning O, Voigt T, Grünert F, Gürtler M, Pferdmenges K, Van Treek H, Möller B, Weigel S, Jun Hassler N, Mauer H, Beckers E, Weber CA, Hawash H, Ladke D, Labitzky G, Kunkel P, Hartung W, Pomykaj T, Prokop H, Schleif T, Cascino L, Exner P, Daelman E, Dietrich A, Prasse T, Brundisch S, Schipper R, Duderstaedt B, De Haan F, Schmidt-Reinwald A, Seidel P, Schmitz J, Bülent E, Ja Pique P, Ding R, Eggeling T, Duderstaedt E, Ferchland HP, Kruth R, Gralla D, Köhler A, Laborge JR, Hammer H, Richter I, Sauldie H, Valk-Denkema IV, Van Der Valk L, Feely J, Dunne L, Cox J, Doyle M, O'Gorman M, Kennedy J, Maher B, Forde D, Harrington P, Cronin B, Coady A, Craig J, O'Dowd C, O'Doherty B, O'Connor P, Ling R, Perry M, Crowley J, Keaveney L, Townley E, O'Shea E, Regan M, Cunningham S, Bluett D, Whyte O, Casey M, Ruane F, Fitzgerald E, O'Beirn E, Faller E, Moffatt S, Coleman M, Day B, Mcadam B, O'Neill D, Mac Mahon C, Wheeler M, Byrne S, Fulcher K, CAREY O, O'Connell K, Keane J, Almarsomi L, Vaughan C, O'Callaghan T, Grufferty T, Shanahan E, Crowley B, Moran J, Cotter J, Healy C, Curtin T, Dillon J, Dennehy T, Murphy E, Kennedy M, Coffey D, Carroll PO, Oliver B, Mccarthy S, Joyce P, O'Shea G, Apperloo AJ, Basart DC, Bax M, Beysens PA, Breed JG, Derks A, Eijgenraam JW, Hermann JP, Janus CL, Kaasjager HA, Klomps HC, Koole MA, Koster T, Kroon C, Lieverse AG, Massaar-Hagen BE, Moghaddam F, Oldenburg-Ligtenberg PC, Potter Van Loon BJ, Stroes ES, Twickler TB, Van Asperdt FG, Van Asseldonk JP, Van Der Loos TL, Van Der Velde RY, 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Abstract

AIM:

To assess the prevalence of persistent lipid abnormalities in statin-treated patients with diabetes with and without the metabolic syndrome.

METHODS:

This was a cross-sectional study of 22,063 statin-treated outpatients consecutively recruited by clinicians in Canada and 11 European countries. Patient cardiovascular risk factors, risk level, lipid measurements and lipid-modifying medication regimens were recorded.

RESULTS:

Of the 20,129 subjects who had documented diabetes and/or metabolic syndrome status, 41% had diabetes (of whom 86.8% also had the metabolic syndrome). Of those with diabetes, 48.1% were not at total cholesterol target compared with 58% of those without diabetes. Amongst those with diabetes, 41.6 and 41.3% of those with and without the metabolic syndrome, respectively, were not at their LDL cholesterol goal relative to 54.2% of those with metabolic syndrome and without diabetes, and 52% of those with neither condition. Twenty per cent of people with diabetes but without the metabolic syndrome were not at the optimal HDL cholesterol level compared with 9% of those with neither condition. Of people with diabetes and the metabolic syndrome, 49.9% were not at optimal triglyceride level relative to 13.5% of people with neither diabetes nor the metabolic syndrome. Simvastatin was the most commonly prescribed statin (>45%) and the most common statin potency was 20-40 mg/day (simvastatin equivalent). Approximately 14% of patients were taking ezetimibe alone or in combination with a statin.

CONCLUSIONS:

Despite evidence supporting the benefits of lipid modification and international guideline recommendations, statin-treated patients with diabetes had a high prevalence of persistent lipid abnormalities. There is frequently room to optimize therapy through statin dose up-titration and/or addition of other lipid-modifying therapies.

[Indexed for MEDLINE]

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