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Blood Press. 2011 Dec;20(6):370-5. doi: 10.3109/08037051.2011.588484. Epub 2011 Jun 16.

Arterial wave reflection decreases gradually from supine to upright.

Author information

1
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, the Netherlands. b.vandenbogaard@amc.nl

Abstract

BACKGROUND:

An increase in total peripheral resistance (TPR) usually increases arterial wave reflection. During passive head-up tilt (HUT), however, arterial wave reflection decreases with increasing TPR. This study addressed whether arterial wave reflection gradually decreases during HUT.

METHODS:

In 10 healthy volunteers (22-39 years, nine males), we recorded finger arterial pressures in supine position (0°), and 30°and 70°degrees HUT and active standing (90°). Aortic pressure was constructed from the finger pressure signal and hemodynamics were calculated. Arterial wave reflection was quantified as the augmentation index (AIx) and the reflection magnitude (RM).

RESULTS:

During HUT, heart rate increased (p < 0.001), stroke volume and cardiac output decreased (p < 0.001 and p < 0.01), diastolic blood pressure increased (p < 0.001), whereas systolic blood pressure did not change. TPR increased from 0.9 dyn s/cm(5) at 0? to 1.2, 1.4 and 1.4 dyn s/cm(5) at 30°, 70° and 90° (p < 0.001). AIx fell gradually from 25% at 0°to 16%, -1% and -10% at 30°, 70° and 90° (p < 0.001). The RM decreased from 0.572 at 0°to 0.456 at 90° (p < 0.001).

CONCLUSION:

From supine to upright, arterial wave reflection represented as AIx and RM gradually decreases in the presence of increasing TPR.

PMID:
21679013
DOI:
10.3109/08037051.2011.588484
[Indexed for MEDLINE]

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