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Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1495-505. doi: 10.1161/ATVBAHA.110.221135.

Signaling mechanisms that regulate smooth muscle cell differentiation.

Author information

1
Department of Pathology, University of North Carolina, Chapel Hill, NC 27599-7525, USA. cmack@med.unc.edu

Abstract

Extensive studies over the last 30 years have demonstrated that vascular smooth muscle cell (SMC) differentiation and phenotypic modulation is controlled by a dynamic array of environmental cues. The identification of the signaling mechanisms by which these environmental cues regulate SMC phenotype has been more difficult because of our incomplete knowledge of the transcription mechanisms that regulate SMC-specific gene expression. However, recent advances in this area have provided significant insight, and the goal of this review is to summarize the signaling mechanisms by which extrinsic cues control SMC differentiation.

PMID:
21677292
PMCID:
PMC3141215
DOI:
10.1161/ATVBAHA.110.221135
[Indexed for MEDLINE]
Free PMC Article
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